| Item Type | Name |
|
Academic Article
|
Release of nontransmembrane full-length Alzheimer's amyloid precursor protein from the lumenar surface of chromaffin granule membranes.
|
|
Academic Article
|
ERAB contains a putative noncleavable signal peptide.
|
|
Academic Article
|
Glycosylphosphatidylinositol-anchor intermediates associate with triton-insoluble membranes in subcellular compartments that include the endoplasmic reticulum.
|
|
Academic Article
|
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model.
|
|
Academic Article
|
Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease.
|
|
Academic Article
|
Glycosylphosphatidylinositol-anchored proteins play an important role in the biogenesis of the Alzheimer's amyloid beta-protein.
|
|
Academic Article
|
Lipid rafts play an important role in A beta biogenesis by regulating the beta-secretase pathway.
|
|
Academic Article
|
The role of the carboxyl-terminal fragments of amyloid precursor protein in Alzheimer's disease.
|
|
Academic Article
|
New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists.
|
|
Academic Article
|
Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-beta peptide.
|
|
Academic Article
|
The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice.
|
|
Academic Article
|
Genotoxicity in Alzheimer's disease: role of amyloid.
|
|
Academic Article
|
Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin.
|
|
Academic Article
|
TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets.
|
|
Academic Article
|
Role of DNA dynamics in Alzheimer's disease.
|
|
Academic Article
|
Early-life events may trigger biochemical pathways for Alzheimer's disease: the "LEARn" model.
|
|
Academic Article
|
Neuronutrition and Alzheimer's disease.
|
|
Academic Article
|
Vitamin D3-enriched diet correlates with a decrease of amyloid plaques in the brain of A?PP transgenic mice.
|
|
Academic Article
|
APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity.
|
|
Academic Article
|
DNA replication-blocking properties of adducts formed by aflatoxin B1-2,3-dichloride and aflatoxin B1-2,3-oxide.
|
|
Academic Article
|
Study of the phorbol ester effect on Alzheimer amyloid precursor processing: sequence requirements and involvement of a cholera toxin sensitive protein.
|
|
Academic Article
|
Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells.
|
|
Academic Article
|
The heat shock/oxidative stress connection. Relevance to Alzheimer disease.
|
|
Academic Article
|
Gene structure and organization of the human beta-secretase (BACE) promoter.
|
|
Academic Article
|
Functional characterization of the 5' flanking region of the BACE gene: identification of a 91 bp fragment involved in basal level of BACE promoter expression.
|
|
Academic Article
|
Differential expression of cholesterol hydroxylases in Alzheimer's disease.
|
|
Academic Article
|
Rationale for the development of cholinesterase inhibitors as anti-Alzheimer agents.
|
|
Academic Article
|
Human retina D2 receptor cDNAs have multiple polyadenylation sites and differ from a pituitary clone at the 5' non-coding region.
|
|
Academic Article
|
Insulysin cleaves the APP cytoplasmic fragment at multiple sites.
|
|
Academic Article
|
An increase in Abeta42 in the prefrontal cortex is associated with a reversal-learning impairment in Alzheimer's disease model Tg2576 APPsw mice.
|
|
Academic Article
|
Pigment epithelium-derived factor maintains retinal pigment epithelium function by inhibiting vascular endothelial growth factor-R2 signaling through gamma-secretase.
|
|
Academic Article
|
Targets for AD treatment: conflicting messages from ?-secretase inhibitors.
|
|
Academic Article
|
Mechanisms of mutagenesis by a bulky DNA lesion at the guanine N7 position.
|
|
Academic Article
|
Sequence context effects in DNA replication blocks induced by aflatoxin B1.
|
|
Academic Article
|
The Alzheimer's amyloid precursor is cleaved intracellularly in the trans-Golgi network or in a post-Golgi compartment.
|
|
Concept
|
Thalidomide
|
|
Concept
|
Cytokines
|
|
Concept
|
Enzyme-Linked Immunosorbent Assay
|
|
Concept
|
Age Factors
|
|
Concept
|
Disease Models, Animal
|
|
Concept
|
Incretins
|
|
Concept
|
Retinal Pigment Epithelium
|
|
Concept
|
Drug Administration Schedule
|
|
Concept
|
Chondroitin Sulfate Proteoglycans
|
|
Concept
|
Fluoresceins
|
|
Concept
|
Methionine
|
|
Concept
|
Amyloid beta-Protein Precursor
|
|
Concept
|
Thiazoles
|
|
Concept
|
Protein Processing, Post-Translational
|
|
Concept
|
ADAM Proteins
|
|
Concept
|
Genes, cdc
|
|
Concept
|
Restriction Mapping
|
|
Concept
|
Microscopy, Video
|
|
Concept
|
Incidence
|
|
Concept
|
Introns
|
|
Concept
|
Genetic Therapy
|
|
Concept
|
Rats, Inbred Strains
|
|
Concept
|
Magnetic Resonance Imaging
|
|
Concept
|
Phosphoinositide Phospholipase C
|
|
Concept
|
Guanidine
|
|
Concept
|
Trisomy
|
|
Concept
|
Receptors, Dopamine
|
|
Concept
|
Drosophila melanogaster
|
|
Concept
|
Dietary Fats
|
|
Concept
|
Fluorescent Dyes
|
|
Concept
|
Cholinesterase Inhibitors
|
|
Concept
|
Insulysin
|
|
Concept
|
Mice, Inbred BALB C
|
|
Concept
|
DNA, Complementary
|
|
Concept
|
Fluorescent Antibody Technique
|
|
Concept
|
Polyethylene Glycols
|
|
Concept
|
Alcohol Drinking
|
|
Concept
|
Pituitary Gland
|
|
Concept
|
Cell Survival
|
|
Concept
|
Aflatoxin B1
|
|
Concept
|
Electrophoresis, Gel, Two-Dimensional
|
|
Concept
|
Mannose
|
|
Concept
|
Treatment Outcome
|
|
Concept
|
Administration, Cutaneous
|
|
Concept
|
Pyrrolidonecarboxylic Acid
|
|
Concept
|
Golgi Apparatus
|
|
Concept
|
Chelation Therapy
|
|
Concept
|
Tretinoin
|
|
Concept
|
GTP-Binding Proteins
|
|
Concept
|
Genomics
|
|
Concept
|
Serpins
|
|
Concept
|
Cricetinae
|
|
Concept
|
Administration, Oral
|
|
Concept
|
Tacrine
|
|
Concept
|
Transcription Initiation Site
|
|
Concept
|
Molecular Biology
|
|
Concept
|
Aflatoxins
|
|
Concept
|
Amino Acid Substitution
|
|
Concept
|
Vitamin E
|
|
Concept
|
Tartrates
|
|
Concept
|
Double-Blind Method
|
|
Concept
|
Drug Delivery Systems
|
|
Concept
|
Mice, Knockout
|
|
Concept
|
Rodentia
|
|
Concept
|
Hydroxamic Acids
|
|
Concept
|
Stroke
|
|
Concept
|
Mice, Inbred C3H
|
|
Concept
|
Chromosomes, Artificial, Yeast
|
|
Concept
|
Inositol
|
|
Concept
|
Precipitin Tests
|
|
Concept
|
Guanine
|
|
Concept
|
Blotting, Western
|
|
Concept
|
Environmental Exposure
|
|
Concept
|
T-Lymphocytes, Regulatory
|
|
Concept
|
Iodine Radioisotopes
|
|
Concept
|
Cricetulus
|
|
Concept
|
Longevity
|
|
Concept
|
T-Lymphocyte Subsets
|
|
Concept
|
Glioma
|
|
Concept
|
Up-Regulation
|
|
Concept
|
Lipoxins
|
|
Concept
|
Caspase 3
|
|
Concept
|
Protein Synthesis Inhibitors
|
|
Concept
|
Mice
|
|
Concept
|
Retinaldehyde
|
|
Concept
|
Clinical Trials as Topic
|
|
Concept
|
Aging
|
|
Concept
|
Tritium
|
|
Concept
|
Aqueous Humor
|
|
Concept
|
Endopeptidases
|
|
Concept
|
Cysteine
|
|
Concept
|
Estrogen Replacement Therapy
|
|
Concept
|
Histocytochemistry
|
|
Concept
|
Kinetics
|
|
Concept
|
Drug Evaluation, Preclinical
|
|
Concept
|
Linear Models
|
|
Concept
|
Cell Adhesion Molecules, Neuron-Glia
|
|
Concept
|
Lipoxygenase
|
|
Concept
|
Receptors, Muscarinic
|
|
Concept
|
Tumor Necrosis Factor-alpha
|
|
Concept
|
Acetylcholinesterase
|
|
Concept
|
Phosphatidylinositol Diacylglycerol-Lyase
|
|
Concept
|
Chromatography, High Pressure Liquid
|
|
Concept
|
Proteoglycans
|
|
Concept
|
Dopamine
|
|
Concept
|
Eye
|
|
Concept
|
Estrogens
|
|
Concept
|
Exons
|
|
Concept
|
Diabetes Mellitus, Type 2
|
|
Concept
|
5' Flanking Region
|
|
Concept
|
Glucosamine
|
|
Concept
|
Azirines
|
|
Concept
|
Mice, Inbred C57BL
|
|
Concept
|
Cholesterol, Dietary
|
|
Concept
|
Retrospective Studies
|
|
Concept
|
Repetitive Sequences, Nucleic Acid
|
|
Concept
|
Gene Expression Regulation
|
|
Concept
|
Enzyme Activation
|
|
Concept
|
Chromosomes, Mammalian
|
|
Concept
|
Sequence Deletion
|
|
Concept
|
Tocopherols
|
|
Concept
|
Mice, Transgenic
|
|
Concept
|
Receptors, Nicotinic
|
|
Concept
|
Receptors, Formyl Peptide
|
|
Concept
|
Manganese
|
|
Concept
|
Benzothiazoles
|
|
Concept
|
Homocysteine
|
|
Concept
|
Drosophila
|
|
Concept
|
DNA Mutational Analysis
|
|
Concept
|
Nucleic Acid Conformation
|
|
Concept
|
Phenanthrolines
|
|
Concept
|
Severity of Illness Index
|
|
Concept
|
Cell Proliferation
|
|
Concept
|
Docosahexaenoic Acids
|
|
Concept
|
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
|
|
Concept
|
Humans
|
|
Concept
|
Hearing Loss
|
|
Concept
|
Down-Regulation
|
|
Concept
|
Hot Temperature
|
|
Concept
|
Cattle
|
|
Concept
|
Cytosine Nucleotides
|
|
Concept
|
Mutation
|
|
Concept
|
Membrane Glycoproteins
|
|
Concept
|
DNA, Viral
|
|
Concept
|
Hyperlipoproteinemia Type II
|
|
Concept
|
DNA, Bacterial
|
|
Concept
|
Receptors, Dopamine D2
|
|
Concept
|
Escherichia coli
|
|
Concept
|
Reactive Oxygen Species
|
|
Concept
|
Rabbits
|
|
Concept
|
Triglycerides
|
|
Concept
|
Carbachol
|
|
Concept
|
Estradiol
|
|
Concept
|
5' Untranslated Regions
|
|
Concept
|
Silver Staining
|
|
Concept
|
Uridine Diphosphate N-Acetylglucosamine
|
|
Concept
|
Genes, Reporter
|
|
Concept
|
Caspases
|
|
Concept
|
Cholera Toxin
|
|
Concept
|
Brain Injuries
|
|
Concept
|
Chromosomes, Human, Pair 11
|
|
Concept
|
Receptors, Glucagon
|
|
Concept
|
Down Syndrome
|
|
Concept
|
Antibodies, Monoclonal
|
|
Concept
|
Retina
|
|
Concept
|
Epigenesis, Genetic
|
|
Concept
|
Alkaline Phosphatase
|
|
Concept
|
Sex Factors
|
|
Concept
|
Analysis of Variance
|
|
Concept
|
Gene Knock-In Techniques
|
|
Concept
|
Reverse Transcriptase Polymerase Chain Reaction
|
|
Concept
|
Protease Inhibitors
|
|
Concept
|
Cystathionine beta-Synthase
|
|
Concept
|
Recombinant Fusion Proteins
|
|
Concept
|
Interleukin-1beta
|
|
Concept
|
Cell Culture Techniques
|
|
Concept
|
Models, Genetic
|
|
Concept
|
Endosomes
|
|
Concept
|
Response Elements
|
|
Concept
|
Alzheimer Disease
|
|
Concept
|
Glycosylphosphatidylinositols
|
|
Concept
|
Immunoglobulin Isotypes
|
|
Concept
|
Dipeptides
|
|
Concept
|
Transduction, Genetic
|
|
Concept
|
Amyloid Precursor Protein Secretases
|
|
Concept
|
Genotype
|
|
Concept
|
Rats, Inbred F344
|
|
Concept
|
Polymorphism, Genetic
|
|
Concept
|
Lymph Nodes
|
|
Concept
|
Cycloheximide
|
|
Concept
|
Radioisotope Dilution Technique
|
|
Concept
|
Case-Control Studies
|
|
Concept
|
Mice, Inbred Strains
|
|
Concept
|
3-Hydroxyacyl CoA Dehydrogenases
|
|
Concept
|
Gene Expression Regulation, Neoplastic
|
|
Concept
|
Extracellular Signal-Regulated MAP Kinases
|
|
Concept
|
Guinea Pigs
|
|
Concept
|
Energy Intake
|
|
Concept
|
Prospective Studies
|
|
Concept
|
Rats
|
|
Concept
|
Autoradiography
|
|
Concept
|
Vitreous Body
|
|
Concept
|
Fetus
|
|
Concept
|
Type C Phospholipases
|
|
Concept
|
Axonal Transport
|
|
Concept
|
Butyrylcholinesterase
|
|
Concept
|
Enzyme Inhibitors
|
|
Concept
|
Rats, Wistar
|
|
Concept
|
Aspartic Acid Endopeptidases
|
|
Concept
|
Transfection
|
|
Concept
|
Point Mutation
|
|
Concept
|
Hydrolysis
|
|
Concept
|
Mice, Neurologic Mutants
|
|
Concept
|
Gene Frequency
|
|
Concept
|
Rats, Sprague-Dawley
|
|
Concept
|
Polymerase Chain Reaction
|
|
Concept
|
Swine
|
|
Concept
|
Hippocampus
|
|
Concept
|
Models, Neurological
|
|
Concept
|
Culture Media, Conditioned
|
|
Concept
|
Hypercholesterolemia
|
|
Concept
|
Trypsin
|
|
Concept
|
Genetic Vectors
|
|
Concept
|
Sequence Analysis, Protein
|
|
Concept
|
MicroRNAs
|
|
Concept
|
Hydrogen-Ion Concentration
|
|
Concept
|
Risk Factors
|
|
Concept
|
Promoter Regions, Genetic
|
|
Concept
|
Epoxy Compounds
|
|
Concept
|
Brain Infarction
|
|
Concept
|
Phosphatidylinositol 3-Kinases
|
|
Concept
|
Vitamins
|
|
Concept
|
Metalloendopeptidases
|
|
Concept
|
DNA, Z-Form
|
|
Concept
|
Base Sequence
|
|
Concept
|
Plasmids
|
|
Concept
|
Follow-Up Studies
|
|
Concept
|
Cloning, Molecular
|
|
Concept
|
Templates, Genetic
|
|
Concept
|
Autopsy
|
|
Concept
|
Glucagon-Like Peptide 1
|
|
Concept
|
Amyloid beta-Peptides
|
|
Concept
|
Immunohistochemistry
|
|
Concept
|
Choline
|
|
Concept
|
DNA, Single-Stranded
|
|
Concept
|
Hybridomas
|
|
Concept
|
Cold Temperature
|
|
Concept
|
Gene Transfer Techniques
|
|
Concept
|
Mice, Mutant Strains
|
|
Concept
|
Immunoblotting
|
|
Concept
|
Cell Count
|
|
Concept
|
Estrogen Receptor alpha
|
|
Concept
|
Deafness
|
|
Academic Article
|
Amyloid-? precursor protein synthesis inhibitors for Alzheimer's disease treatment.
|
|
Academic Article
|
Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease.
|
|
Academic Article
|
When figures and data contradict text: MiR346 is apparently reduced in breast cancer tissue, contrary to claims by a paper's author.
|
|
Academic Article
|
Indoles as essential mediators in the gut-brain axis. Their role in Alzheimer's disease.
|
|
Academic Article
|
Correction: Rivastigmine modifies the a-secretase pathway and potentially early Alzheimer's disease.
|
|
Academic Article
|
Rivastigmine modifies the a-secretase pathway and potentially early Alzheimer's disease.
|
|
Concept
|
Plaque, Amyloid
|
|
Concept
|
Glucagon-Like Peptide-1 Receptor
|
|
Concept
|
Gastrointestinal Microbiome
|
|
Concept
|
ADAM17 Protein
|
|
Concept
|
Endothelin-Converting Enzymes
|
|
Academic Article
|
Sex-Specific Regulation of ?-Secretase: A Novel Estrogen Response Element (ERE)-Dependent Mechanism in Alzheimer's Disease.
|
|
Academic Article
|
Mechanistic Insights Into Gut Microbiome Dysbiosis-Mediated Neuroimmune Dysregulation and Protein Misfolding and Clearance in the Pathogenesis of Chronic Neurodegenerative Disorders.
|
|
Academic Article
|
The role of the adaptive immune system and T cell dysfunction in neurodegenerative diseases.
|
|
Academic Article
|
The lymphatic system in neurological disease and Alzheimer's disease. A brief Editorial.
|
|
Academic Article
|
Current Advances in Adeno-Associated Virus-Mediated Gene Therapy to Prevent Acquired Hearing Loss.
|